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Proceedings Paper

Brain proton magnetic resonance spectroscopy for hepatic encephalopathy
Author(s): Chin-Sing Ong; James R. McConnell; Wei-Kom Chu
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Paper Abstract

Liver failure can induce gradations of encephalopathy from mild to stupor to deep coma. The objective of this study is to investigate and quantify the variation of biochemical compounds in the brain in patients with liver failure and encephalopathy, through the use of water- suppressed, localized in-vivo Proton Magnetic Resonance Spectroscopy (HMRS). The spectral parameters of the compounds quantitated are: N-Acetyl Aspartate (NAA) to Creatine (Cr) ratio, Choline (Cho) to Creatine ratio, Inositol (Ins) to Creatine ratio and Glutamine-Glutamate Amino Acid (AA) to Creatine ratio. The study group consisted of twelve patients with proven advanced chronic liver failure and symptoms of encephalopathy. Comparison has been done with results obtained from five normal subjects without any evidence of encephalopathy or liver diseases.

Paper Details

Date Published: 27 August 1993
PDF: 3 pages
Proc. SPIE 1887, Physiological Imaging, Spectroscopy, and Early-Detection Diagnostic Methods, (27 August 1993); doi: 10.1117/12.151176
Show Author Affiliations
Chin-Sing Ong, Univ. of Nebraska Medical Ctr. (United States)
James R. McConnell, Univ. of Nebraska Medical Ctr. (United States)
Wei-Kom Chu, Univ. of Nebraska Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 1887:
Physiological Imaging, Spectroscopy, and Early-Detection Diagnostic Methods
Randall Locke Barbour; Mark J. Carvlin, Editor(s)

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