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Proceedings Paper

Classification of ductal carcinoma in-situ by image analysis of calcifications from mammograms
Author(s): Jon Parker; David R. Dance; David H. Davies; L. J. Yeoman; M. J. Michell; S. Humphreys
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Paper Abstract

Image analysis methods have been developed to characterize calcifications associated with Ductal Carcinoma in-Situ (DCIS), and to differentiate between those having comedo or non- comedo histology. Cases were selected from the U.K. breast screening program, and in each case the histology and a magnified mammographic view were obtained. The films were digitized at 25 micron sampling size and 8 bit grey level resolution. Calcifications were manually segmented from the normal breast background, and a radiologist, experienced in breast screening, checked the labelling of a calcifications. An algorithm was developed to classify firstly the individual objects within a film, and secondly the film itself. The algorithm automatically selected the combination of features giving the least estimated Bayes error for a set of object-oriented features evaluated for each calcification. The k-nearest neighbors statistical approach was then used to classify individual objects giving a ratio of comedo to non-comedo objects for a set of training films. Films were classified by applying a threshold to this ratio. In the classification of typical comedo from typical non-comedo the success rate of the algorithm was 100% for a training set of 4 cases and test set of 16 cases.

Paper Details

Date Published: 29 July 1993
PDF: 9 pages
Proc. SPIE 1905, Biomedical Image Processing and Biomedical Visualization, (29 July 1993); doi: 10.1117/12.148695
Show Author Affiliations
Jon Parker, Institute of Cancer Research and Royal Marsden Hospital (United Kingdom)
David R. Dance, Institute of Cancer Research and Royal Marsden Hospital (United Kingdom)
David H. Davies, Institute of Cancer Research and Royal Marsden Hospital (United Kingdom)
L. J. Yeoman, King's College Hospital (United Kingdom)
M. J. Michell, King's College Hospital (United Kingdom)
S. Humphreys, King's College Hospital (United Kingdom)

Published in SPIE Proceedings Vol. 1905:
Biomedical Image Processing and Biomedical Visualization
Raj S. Acharya; Dmitry B. Goldgof, Editor(s)

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