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Proceedings Paper

Measurement of the erythrocyte response to low-level external action
Author(s): Stanislav D. Zakharov
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Paper Abstract

The problem of unique sensitivity of living cells to weak forces and fields remains to be solved. A generally accepted principle of investigations of the cell amplification mechanisms is that of detailing. As a result all the more structural and chemical details have been discovered in regard to biological processes. Unfortunately the living system has been broken down into artificial fragments and a prospect has been removed to reveal how the details are united in real time allowing a cell to accept low-energy signals and to respond adequately to them. According to our conception the native cell self must be used as a measuring instrument for resolution of this problem. Internal organization and operation of the living cell can be understood by way of variations of nature and parameters of external forces and recording the cell response by a suitable technique. In this report a simple and sensitive technique of the red blood cell (RBC) response includes the creation of circulating RBC flow, the RBC's hydrodynamic orienting and plane focusing in an optical cell with parabolic profile of velocities, and application of Fraunhofer diffraction analysis to detect changes of the plane position as a result of the cell exposure to low-level action. As examples of such action the low-intensity laser irradiation and temperature-induced changes are presented.

Paper Details

Date Published: 21 July 1993
PDF: 9 pages
Proc. SPIE 1884, Static and Dynamic Light Scattering in Medicine and Biology, (21 July 1993); doi: 10.1117/12.148366
Show Author Affiliations
Stanislav D. Zakharov, ODER R&D Ctr. (Russia)

Published in SPIE Proceedings Vol. 1884:
Static and Dynamic Light Scattering in Medicine and Biology
Ralph J. Nossal; Robert Pecora; Alexander V. Priezzhev, Editor(s)

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