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Proceedings Paper

Medical applications of laser-induced fluorescence: pharmacokinetics of photosensitizers
Author(s): Kevin T. Schomacker; Joan K. Frisoli; Thomas F. Deutsch
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Paper Abstract

Laser-induced fluorescence has been used to measure tissue levels of chloroaluminum phthalocyanine tetrasulfonate versus time in order to determine its pharmacokinetics. A hamster cheek pouch carcinoma model was used in vivo. The data have been modeled using a four compartment pharmacokinetic model, yielding rate constants which describe the transport. A minimum of 13 rate constants was needed to achieve acceptable fits to the tumor and normal tissue as well as plasma data. The model gives insight into the role of binding and unbinding processes that are not otherwise evident.

Paper Details

Date Published: 7 July 1993
PDF: 9 pages
Proc. SPIE 1882, Laser-Tissue Interaction IV, (7 July 1993); doi: 10.1117/12.147686
Show Author Affiliations
Kevin T. Schomacker, Wellman Labs. of Photomedicine/Massachusetts General Hospital (United States)
Joan K. Frisoli, Wellman Labs. of Photomedicine/Massachusetts General Hospital (United States)
Thomas F. Deutsch, Wellman Labs. of Photomedicine/Massachusetts General Hospital (United States)


Published in SPIE Proceedings Vol. 1882:
Laser-Tissue Interaction IV
Steven L. Jacques; Abraham Katzir, Editor(s)

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