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Proceedings Paper

Laser microirradiation of single nerve cell
Author(s): Anatoly B. Uzdensky
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Paper Abstract

Isolated crayfish mechanoreceptor neuron was microirradiated into its different region with various lasers (mainly with helium-cadmium laser, 441.6 nm). Laser microbeam was about 5 - 9 micrometers , intensity varied from 101 to 1.5(DOT)104 W/cm2, and wavelength--from 454 to 633 nm. Polyphasic neuron response on laser microirradiation (impulse frequency acceleration, then inhibition, new acceleration, and sudden irreversible impulsation ceasing) was described and its dependence on intensity, wavelength and localization was investigated. Complex electrophysiological, ultrastructural and cytochemical study along with results of neuron response modification with supravital stains, bioenergetic inhibitors, antioxidants gave evidences that impulsation acceleration phases were caused by laser effect on neuronal membrane, but inhibition phase--on mitochondria. Main intracellular laser radiation photoreceptors were probably flavins.

Paper Details

Date Published: 7 July 1993
PDF: 14 pages
Proc. SPIE 1882, Laser-Tissue Interaction IV, (7 July 1993); doi: 10.1117/12.147682
Show Author Affiliations
Anatoly B. Uzdensky, Rostov State Univ. (Russia)


Published in SPIE Proceedings Vol. 1882:
Laser-Tissue Interaction IV
Steven L. Jacques; Abraham Katzir, Editor(s)

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