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Proceedings Paper

Lower power interstitial laser photocoagulation in rat liver: importance of fiber type, laser wavelength, and tissue charring
Author(s): Zahir Amin; Giovanni A. Buonaccorsi; Timothy N. Mills; Simon A. Harries; William R. Lees; Stephen G. Bown
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Paper Abstract

To evaluate whether the size of the tissue necrosis achieved by interstitial laser photocoagulation (ILP) is dependent on the fiber core diameter, the fiber cladding, and the laser wavelength used. Methods: Forty six rats were anaesthetized and their livers exposed at laparotomy. A single bare fiber was inserted interstitially into the liver which was then irradiated at 2 W for 100 s or 500 s. Four fibers were used: 0.2 mm and 0.4 mm all silica fibers had their buffer coats/jackets stripped off the distal 3 mm, leaving the cladding intact; 0.2 mm and 0.4 mm plastic clad fibers had their buffer coats/jackets and cladding stripped off the distal 3 mm. A 1064 nm Nd:YAG and an 805 nm diode laser were used. One day after ILP the rats were sacrificed and measurements made of the size of necrosis and of any charring. Results: 1. There was no difference in the size of necrosis from a 0.2 mm or 0.4 mm fiber. 2. Larger areas of necrosis and greater charring were produced with the plastic clad fibers. 3. The 805 nm diode laser gave the largest necrotic size and the greatest charring for a given energy. 4. There was a positive correlation between the degree of charring and the size of the necrosis.

Paper Details

Date Published: 7 July 1993
PDF: 11 pages
Proc. SPIE 1882, Laser-Tissue Interaction IV, (7 July 1993); doi: 10.1117/12.147657
Show Author Affiliations
Zahir Amin, National Medical Laser Ctr./Univ. College London, and Middlesex Hospital (United Kingdom)
Giovanni A. Buonaccorsi, National Medical Laser Ctr./Univ. College London (United Kingdom)
Timothy N. Mills, National Medical Laser Ctr./Univ. College London (United Kingdom)
Simon A. Harries, National Medical Laser Ctr./Univ. College London (United Kingdom)
William R. Lees, Middlesex Hospital (United Kingdom)
Stephen G. Bown, National Medical Laser Ctr./Univ. College London (United Kingdom)


Published in SPIE Proceedings Vol. 1882:
Laser-Tissue Interaction IV
Steven L. Jacques; Abraham Katzir, Editor(s)

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