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Proceedings Paper

Early diagnosis of substance-specific alterations in primary open-angle glaucoma by means of fundus spectrometry
Author(s): Dietrich Schweitzer; Mateusz Scibor; Martin Hammer; Sabine Guenther
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Paper Abstract

A double beam spectrometer, which works in single photon counting technique, was developed for measuring the reflectance spectra at selected fundus sites in a wavelength range from 430 to 700 nm. By forming logarithmic difference spectra between the reflectance of the normal fundus and the fundus reflectance in different stages of glaucoma only substance or structure specific glaucomatous alterations appear. The approximation of logarithmic difference spectra is demonstrated by a linear model. The primary information in the modelling is only the relative spectral course of important fundus substances like oxyhemoglobin, melanin and xanthophyll. The influence of scattering is formulated as a wavelength-independent intensity, multiplied by a term, containing a power of the wavelength. Found by the spectra-deconvolution, a lack of oxyhemoglobin in the papillo-macular bundle is the first sign of a damaged microcirculation in case of relative losses of the visual field function. The reduced scattering intensity and the altered scattering exponent point to a thinning of the nerve fiber layer.

Paper Details

Date Published: 24 June 1993
PDF: 8 pages
Proc. SPIE 1877, Ophthalmic Technologies III, (24 June 1993); doi: 10.1117/12.147532
Show Author Affiliations
Dietrich Schweitzer, Univ. of Jena (Germany)
Mateusz Scibor, Univ. of Jena (Germany)
Martin Hammer, Univ. of Jena (Germany)
Sabine Guenther, Univ. of Jena (Germany)

Published in SPIE Proceedings Vol. 1877:
Ophthalmic Technologies III
Jean-Marie A. Parel; Qiushi Ren, Editor(s)

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