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Proceedings Paper

Fluorescence-based tissue biopsy needle: in vivo optical diagnosis in rat model with low cost, arc-lamp-based system
Author(s): Karlheinz Strobl; Sandor G. Vari; Theodore G. Papazoglou; Warren S. Grundfest; Doug M. Brenner
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Paper Abstract

The diagnostic capability of an optical biopsy probe combined with a tumor selective fluorescence drug (Photofrin IIR) was tested in an in vivo animal model. The optical biopsy system is comprised of an arc lamp, an optical contact probe, and low cost detectors. We illuminated tissue with blue (405 nm) light and detected the diffusely reflected excitation light, the tissue autofluorescence (500 - 540 nm), and the drug fluorescence near 630 nm. By using the appropriate signal ratios, normal, inflamed and malignant lymph nodes could be distinguished with a high specificity and sensitivity (85 - 95%).

Paper Details

Date Published: 7 July 1993
PDF: 10 pages
Proc. SPIE 1892, Medical Lasers and Systems II, (7 July 1993); doi: 10.1117/12.147494
Show Author Affiliations
Karlheinz Strobl, Cogent Light Technology (United States)
Sandor G. Vari, Cedars-Sinai Medical Ctr. (United States)
Theodore G. Papazoglou, Institute of Electronic Structure and Laser (Greece)
Warren S. Grundfest, Cedars-Sinai Medical Ctr. (United States)
Doug M. Brenner, Cogent Light Technologies (United States)

Published in SPIE Proceedings Vol. 1892:
Medical Lasers and Systems II
David M. Harris; Carl Murray Penney; Abraham Katzir, Editor(s)

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