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Proceedings Paper

Evaluation of multidirectional fluorescence-sensing laser catheter for the development of an intelligent laser angioplasty system
Author(s): Takayuki Asahara; Mikio Usui; Takashi Amemiya; Yasuhisa Oike; Hiromori Shiraishi; Manabu Miyagi; Hitoshi Nakajima; Tomitsugu Kato; Yuichi Naito; Chiharu Ibukiyama; Katsuo Aizawa; Hiromi Tominaga; Isako Hoshino
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Paper Abstract

The differential diagnostic capacity of a multi-directional sensing catheter with intraluminal objects was evaluated by fluorescence analysis following administration of a photosensitizer. The measurement catheter is 1.7 mm in diameter and is constructed with a cross-sectional arrangement of 6 sensor bundle units and a centered guide wire lumen. Fluorescence was analyzed by polychrometer and amplified CCD camera with an image intensifier. The excitation light was 405 nm wavelength obtained from an Xe-Hg lamp using a band pass filter. In vivo and in vitro fluorescence analysis of normal and atherosclerotic rabbit aorta was performed following intravenous administration of 5 mg/kg hematoporphyrin derivatives (HpD) 24 hours before. The multi-directional sensing catheter detected fluorescence spectra independently in real time. In vivo measurement of this catheter showed, relative to the tip of catheter, in which direction there was blood, normal intima, slight intimal thickness, which should not be treated by laser, or areas of atherosclerosis, which can be treated by laser.

Paper Details

Date Published: 23 June 1993
PDF: 6 pages
Proc. SPIE 1878, Diagnostic and Therapeutic Cardiovascular Interventions III, (23 June 1993); doi: 10.1117/12.146590
Show Author Affiliations
Takayuki Asahara, Tokyo Medical College (Japan)
Mikio Usui, Tokyo Medical College (Japan)
Takashi Amemiya, Tokyo Medical College (Japan)
Yasuhisa Oike, Tokyo Medical College (Japan)
Hiromori Shiraishi, Tokyo Medical College (Japan)
Manabu Miyagi, Tokyo Medical College (Japan)
Hitoshi Nakajima, Tokyo Medical College (Japan)
Tomitsugu Kato, Tokyo Medical College (Japan)
Yuichi Naito, Tokyo Medical College (Japan)
Chiharu Ibukiyama, Tokyo Medical College (Japan)
Katsuo Aizawa, Tokyo Medical College (Japan)
Hiromi Tominaga, Medical Science Co. (Japan)
Isako Hoshino, Medical Science Co. (Japan)


Published in SPIE Proceedings Vol. 1878:
Diagnostic and Therapeutic Cardiovascular Interventions III
George S. Abela, Editor(s)

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