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Proceedings Paper

Dual imaging of arterial walls: intravascular ultrasound and fluorescence spectroscopy
Author(s): Karl A. Pope; Steve Warren; Youseph Yazdi; Alfred L. Johnston; Michael Davis; Rebecca R. Richards-Kortum
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Paper Abstract

This paper describes a combined ultrasonic and spectroscopic system for imaging both the structure and chemical composition of atherosclerotic plaque. Using this system, ultrasound pulse echo distance estimations can be used to accurately compensate detected tissue fluorescence intensities for a wide range of tissue-detector separations, D. Compensation is achieved using an empirical model, wherein fluorescence intensity decreases as 1/Dn with n equals 1.1 for tissue detector separations from 2.5 to 5 mm and 1.4 for separations of 5 to 15 mm. This behavior indicates that fluorescence exiting the tissue surface is not isotropic.

Paper Details

Date Published: 23 June 1993
PDF: 9 pages
Proc. SPIE 1878, Diagnostic and Therapeutic Cardiovascular Interventions III, (23 June 1993); doi: 10.1117/12.146589
Show Author Affiliations
Karl A. Pope, Univ. of Texas/Austin (United States)
Steve Warren, Univ. of Texas/Austin (United States)
Youseph Yazdi, Univ. of Texas/Austin (United States)
Alfred L. Johnston, Univ. of Texas Medical Branch/Galveston (United States)
Michael Davis, Univ. of Texas Medical Branch/Galveston (United States)
Rebecca R. Richards-Kortum, Univ. of Texas/Austin (United States)

Published in SPIE Proceedings Vol. 1878:
Diagnostic and Therapeutic Cardiovascular Interventions III
George S. Abela, Editor(s)

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