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Proceedings Paper

Vapor bubble expansion and implosion: the origin of "Mille Feuilles"
Author(s): Ton G. J. M. van Leeuwen; Lieselotte van Erven; John H. Meertens; Mark J. Post; Cornelius Borst
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Paper Abstract

The aim of our study was to demonstrate, in vivo, bubble expansion in blood and to assess any damage to the arterial wall after 1 - 10 excimer laser pulses (55 mJ/mm2). Time resolved flash photography demonstrated the expansion and implosion of a vapor bubble, which induced a 50% diameter increase of the artery within 75 microsecond(s) and a subsequent invagination (150 - 500 microsecond(s) ). This microsecond dilation and invagination caused extensive wall damage (up to 1.9 mm) far beyond the penetration depth of 308 nm laser light (< 100 micrometers ). The damage, which increased with the number of laser pulses, may be related to the dissections observed after excimer laser coronary angioplasty.

Paper Details

Date Published: 23 June 1993
PDF: 11 pages
Proc. SPIE 1878, Diagnostic and Therapeutic Cardiovascular Interventions III, (23 June 1993); doi: 10.1117/12.146581
Show Author Affiliations
Ton G. J. M. van Leeuwen, Interuniversity Cardiology Institute of the Netherlands (Netherlands)
Lieselotte van Erven, Univ. Hospital Utrecht (Netherlands)
John H. Meertens, Univ. Hospital Utrecht (Netherlands)
Mark J. Post, Interuniversity Cardiology Institute of the Netherlands (Netherlands)
Cornelius Borst, Univ. Hospital Utrecht (Netherlands)


Published in SPIE Proceedings Vol. 1878:
Diagnostic and Therapeutic Cardiovascular Interventions III
George S. Abela, Editor(s)

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