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Proceedings Paper

Chronic response to direct myocardial revascularization: a preliminary study
Author(s): Peter Whittaker; Shi-Ming Zheng; Robert A. Kloner
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Paper Abstract

Anecdotal evidence suggests that laser revascularization has long-term benefits on tissue perfusion, perhaps by stimulating angiogenesis. To test this hypothesis, we made 6 transmural channels in rat hearts randomized to either; (1) laser: channels made using a 500 micrometers diameter optic fiber coupled to a holmium:YAG laser, (2) needle: channels made using a 500 micrometers diameter needle, or (3) control: no channels made. Two months later, the rats underwent 90 minutes of coronary artery occlusion followed by 41/2 hours of reperfusion. Prior to the end of the experiment, the artery was reoccluded and the heart perfused with blue dye to detect collateral perfusion within the risk region. Microscopic analysis revealed more dye-containing vessels in needle-treated hearts than in laser or control groups (12 +/- 6*, 3 +/- 1, 2 +/- 1 vessels per field of view, * p < 0.05). Needle channels also appeared to limit necrosis: infarct size was 41 +/- 6* (needle), 61 +/- 6 (laser), 70 +/- 5 (control) % of the risk region in the three groups (*p < 0.05 versus control). Thus, needle- treatment may be capable of reducing infarct size by supplying blood via a collateral circulation apparently stimulated by the channels making process.

Paper Details

Date Published: 23 June 1993
PDF: 7 pages
Proc. SPIE 1878, Diagnostic and Therapeutic Cardiovascular Interventions III, (23 June 1993); doi: 10.1117/12.146580
Show Author Affiliations
Peter Whittaker, Hospital of the Good Samaritan (United States)
Shi-Ming Zheng, Hospital of the Good Samaritan (United States)
Robert A. Kloner, Hospital of the Good Samaritan (United States)


Published in SPIE Proceedings Vol. 1878:
Diagnostic and Therapeutic Cardiovascular Interventions III
George S. Abela, Editor(s)

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