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Proceedings Paper

Acute effects of short-term intimal heating by laser-heated thermal balloon angioplasty in canine stenotic femoral arteries in vivo
Author(s): Akira Miyamoto; Masami Sakurada; Tsunenori Arai; Kyoichi Mizuno; Yasunori Sugiyabu; Akira Kurita; Haruo Nakamura; Makoto Kikuchi; Tamishige Watanabe; Atsushi Utsumi; Yoshiro Akai; Kiyoshi Takeuchi
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Paper Abstract

Short-term intimal heating may be effective to improve luminal geometry without deep medial injury which can induce restenosis. We developed a new laser-heated thermal balloon catheter which can quickly raise and lower the balloon temperature. To investigate the acute effect of short-term thermal balloon angioplasty (STBA) for stenotic lesions, we performed STBA following balloon angioplasty (BA) in 8 canine stenotic femoral arteries. Cw Nd:YAG laser delivery (10 W, 15 s) induced the maximum temperature of 83 degree(s)C on average. Angiography and angioscopy were performed at pre-BA, post-BA and post-STBA. The angiographical mean stenotic diameter was 1.8 mm at pre-BA, 2.2 mm* at post-BA, 2.9 mm** at post-STBA (*:p < 0.05 pre-BA vs post-BA, **:p < 0.05 pre- and post-BA vs post-STBA). The angioscopic observation revealed intimal flaps and tears in 7 lesions after BA. The luminal geometry after STBA was symmetrically expanded. However, the intimal injury was still observed although the intimal flaps were partly sealed by STBA. These results suggested that the dilatation mechanism of STBA for stenotic lesions might be attributed to preventing elastic recoil rather than to sealing intimal fragments induced by BA.

Paper Details

Date Published: 23 June 1993
PDF: 7 pages
Proc. SPIE 1878, Diagnostic and Therapeutic Cardiovascular Interventions III, (23 June 1993); doi: 10.1117/12.146577
Show Author Affiliations
Akira Miyamoto, National Defense Medical College (Japan)
Masami Sakurada, National Defense Medical College (Japan)
Tsunenori Arai, National Defense Medical College (Japan)
Kyoichi Mizuno, National Defense Medical College (Japan)
Yasunori Sugiyabu, National Defense Medical College (Japan)
Akira Kurita, National Defense Medical College (Japan)
Haruo Nakamura, National Defense Medical College (Japan)
Makoto Kikuchi, National Defense Medical College (Japan)
Tamishige Watanabe, Mitsubishi Cable Ltd. (Japan)
Atsushi Utsumi, Mitsubishi Cable Ltd. (Japan)
Yoshiro Akai, Hamamatsu Photonics Ltd. (Japan)
Kiyoshi Takeuchi, Fukuda Denshi Ltd. (Japan)

Published in SPIE Proceedings Vol. 1878:
Diagnostic and Therapeutic Cardiovascular Interventions III
George S. Abela, Editor(s)

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