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Proceedings Paper

Laser irradiation reduces vasoreactivity of coronary artery: implication for prevention of coronary spasm
Author(s): Takanobu Tomaru; Fumitaka Nakamura; Atsuko Miwa; Yoshiharu Fujimori; Yasumi Uchida
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Paper Abstract

Vasoreactivity of laser-treated coronary artery was investigated in canine left circumflex coronary artery (LCx). Excimer laser (XeCl 308 nm, 50 mJ/mm2), holmium YAG laser (2.1 micrometers , 150 mJ/pulse), or argon laser (488 nm, 3 W), were used through a single optical fiber. Two 3-mm long segments were obtained from the treated segments and controls in Krebs-bicarbonate buffer. Contraction of LCx was induced with KCl at 30 mM or 3,4 DAP and expressed as developed tension (gram; g). Eighteen dogs were used. Reduction of vasocontactility was observed in excimer treated vessels (0.17 +/- 0.24 g with KCl and 0.34 +/- 0.55 g with 3,4 DAP vs 2.13 +/- 0.85 with KCl and 3.1 +/- 1.9 with 3,4 DAP in control, P < 0.001 respectively), holmium YAG treated vessels (0.43 +/- 0.48 g with KCl and 0.46 +/- 0.24 with 3,4 DAP vs 2.42 +/- 0.49 g with KCl and 3.2 +/- 0.46 with 3,4 DAP in control, P < 0.001 respectively) and argon treated vessels (0.48 +/- 0.79 g vs 4.4 +/- 0.88 in control, P < 0.001). Either pulsed or argon laser irradiation results in loss of vasoreactivity to either constrictive or relaxation agent.

Paper Details

Date Published: 23 June 1993
PDF: 4 pages
Proc. SPIE 1878, Diagnostic and Therapeutic Cardiovascular Interventions III, (23 June 1993); doi: 10.1117/12.146576
Show Author Affiliations
Takanobu Tomaru, Univ. of Tokyo (Japan)
Fumitaka Nakamura, Univ. of Tokyo (Japan)
Atsuko Miwa, Univ. of Tokyo (Japan)
Yoshiharu Fujimori, Univ. of Tokyo (Japan)
Yasumi Uchida, Univ. of Tokyo (Japan)


Published in SPIE Proceedings Vol. 1878:
Diagnostic and Therapeutic Cardiovascular Interventions III
George S. Abela, Editor(s)

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