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Proceedings Paper

Influence of ingested ethanol on Photofrin clearance in mice
Author(s): Donna Montague; Louis Fink; Angie Stone; Stephen Thomas Flock
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Paper Abstract

A series of experiments have been undertaken to ascertain the influence of dietary additives on the clearance of Photofrin. Post-treatment cutaneous photosensitivity continues to be a significant side effect of photodynamic therapy (PDT) in humans. Cutaneous photosensitivity in humans is evidenced by erythema and edema in exposed areas. Murine models were chosen to investigate the differences in cutaneous photosensitivity as measured by footpad thickness in the presence or absence of dietary additives. Additionally, radiation induced fibrosarcoma (RIF) cells were implanted into the subcutaneous space on the dorsal aspect of the foot. In this case, the effect of PDT on tumor growth kinetics was assumed to be proportional to Photofrin concentration. Photofrin concentrations in tumors were measured by HPLC. Serum levels for dietary additives were obtained where analytical methods were available. Ingested ethanol increased the clearance rate of Photofrin as demonstrated by measurements of Photofrin tumor concentration and by failure of RIF tumor to respond to PDT in groups treated with ethanol compared to controls.

Paper Details

Date Published: 18 June 1993
PDF: 8 pages
Proc. SPIE 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II, (18 June 1993); doi: 10.1117/12.146332
Show Author Affiliations
Donna Montague, Univ. of Arkansas for Medical Sciences (United States)
Louis Fink, Univ. of Arkansas for Medical Sciences and John L. McClellan Memorial Veterans Hospital (United States)
Angie Stone, John L. McClellan Memorial Veterans Hospital (United States)
Stephen Thomas Flock, Univ. of Arkansas for Medical Sciences (Australia)


Published in SPIE Proceedings Vol. 1881:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II
Thomas J. Dougherty, Editor(s)

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