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Proceedings Paper

Mechanisms contributing to optimization of PDT with first-generation photosensitizers
Author(s): Russell Hilf; Scott L. Gibson; Thomas H. Foster
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Paper Abstract

Improved control of tumor growth has been accomplished by modification of the irradiation scheme applied to hematoporphyrin-induced sensitization. Significantly enhanced efficacy of PDT was seen with either reduction of fluence rate or with an intermittent light-dark protocol, together suggesting that consideration must be given to photochemical oxygen depletion as a rate-limiting component in the production of singlet oxygen, the mediator of cytotoxicity resulting from PDT. A model to explain the basis for the improved efficacy was developed and is being tested by study of homograft and xenograft tumors in vivo and in multicellular tumor spheroids in vitro.

Paper Details

Date Published: 18 June 1993
PDF: 6 pages
Proc. SPIE 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II, (18 June 1993); doi: 10.1117/12.146325
Show Author Affiliations
Russell Hilf, Univ. of Rochester (United States)
Scott L. Gibson, Univ. of Rochester (United States)
Thomas H. Foster, Univ. of Rochester (United States)


Published in SPIE Proceedings Vol. 1881:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II
Thomas J. Dougherty, Editor(s)

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