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Proceedings Paper

Photosensitizer dosage: mg/kg or mg/m2 of body surface?
Author(s): James S. McCaughan; Cynthia Miller
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Paper Abstract

The effect of different doses of the photosensitizer dihematoporphyrin ether (DHE) on the percent decrease of obstruction by endobronchial tumors produced by photodynamic therapy (PDT) was compared on the basis of mg/kg of body weight and mg/m2 of body surface. We found statistically significant differences in the effect of different mg/m2 when there was no difference when compared on the basis of mg/kg of body weight. There was an increase and then a decrease in the effectiveness as the mg/m2 increased. We do not know how to interpret this. However, mg/m2 provides a better parameter for effectiveness and we are now using 60 mg/m2 of DHE for treating endobronchial tumors on the same day as the injection.

Paper Details

Date Published: 18 June 1993
PDF: 9 pages
Proc. SPIE 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II, (18 June 1993); doi: 10.1117/12.146320
Show Author Affiliations
James S. McCaughan, Laser Medical Research Foundation and Grant Laser Ctr. (United States)
Cynthia Miller, Laser Medical Research Foundation and Grant Laser Ctr. (United States)


Published in SPIE Proceedings Vol. 1881:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II
Thomas J. Dougherty, Editor(s)

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