Share Email Print
cover

Proceedings Paper

Immunophototherapy for the treatment of cancer of the larynx
Author(s): Kenneth J. Schlager; Manuel P. Clemente
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

Immunophototherapy (IPT) is an experimental method of medical diagnosis and treatment the seeks to provide for the initial detection and subsequent selective destruction of diseased cancer cells such as the squamous carcinoma cells found in malignant tumors resident in cancer of the larynx. Monoclonal antibodies that are specific to squamous cells will be used to detect and treat this neck cancer. These antibodies are tagged with photosensitive compounds and metal colloids and then intravenously injected into the patient. The tagged antibodies quickly and selectively bind to the squamous cells in the larynx and other affected organs. The cancer cells are then selectively destroyed by irradiation of these complexes with light of the proper wavelength. This light activates the photosensitive material which then creates singlet oxygen that destroys the cells. Toxic products of lysis are quickly discharged from the body by activation of the reticuloendothelial system. IPT has been demonstrated to be very effective in the in vitro selective destruction of specified cell types.

Paper Details

Date Published: 18 June 1993
PDF: 11 pages
Proc. SPIE 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II, (18 June 1993); doi: 10.1117/12.146305
Show Author Affiliations
Kenneth J. Schlager, Biotronics Technologies, Inc. (United States)
Manuel P. Clemente, Oporto School of Medicine (Portugal)


Published in SPIE Proceedings Vol. 1881:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II
Thomas J. Dougherty, Editor(s)

© SPIE. Terms of Use
Back to Top