Share Email Print
cover

Proceedings Paper

Treatment parameters affecting the response of normal brain to photodynamic therapy
Author(s): Qun Chen; Michael Chopp; Mary O. Dereski; Brian C. Wilson; Michael S. Patterson; David Kessel; Larry Heads; Fred W. Hetzel
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Different aspects of photodynamic therapy in normal rat brain tissue have been studied, in an effort to understand and improve the dosimetry of this new modality in treatment of brain tumors. dosimetry parameters, including light energy dose, fluence rate and beam size, and drug dosage were studied. PDT induced lesion depth in brain was measured as a biological endpoint. Effective attenuation depth and absolute light fluence rate distribution under superficial irradiation were measured using invasive optical probes. Photosensitizer uptake was quantified using HPLC analysis. The results indicate that normal brain have a high intrinsic sensitivity to PDT treatment, based on the estimated photodynamic threshold.

Paper Details

Date Published: 18 June 1993
PDF: 7 pages
Proc. SPIE 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II, (18 June 1993); doi: 10.1117/12.146304
Show Author Affiliations
Qun Chen, Henry Ford Hospital (United States)
Michael Chopp, Henry Ford Hospital (United States)
Mary O. Dereski, Henry Ford Hospital (United States)
Brian C. Wilson, Hamilton Regional Cancer Ctr. (Canada)
Michael S. Patterson, Hamilton Regional Cancer Ctr. (Canada)
David Kessel, Wayne State Univ. (United States)
Larry Heads, Henry Ford Hospital (United States)
Fred W. Hetzel, Henry Ford Hospital (United States)


Published in SPIE Proceedings Vol. 1881:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II
Thomas J. Dougherty, Editor(s)

© SPIE. Terms of Use
Back to Top