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Proceedings Paper

Attempts to treat malignant melanoma by photodynamic therapy using bacteriopheophorbide ester as the sensitizer
Author(s): Joerg G. Moser
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Paper Abstract

Quantitative data are presented on uptake and phototoxicity of the photosensitizing drug, 132 hydroxy bacteriopheophorbide a methyl ester, in three cell lines of melanotic (SkMel 25) and amelanotic (A375, Melur SP 18) melanoma. A375 is the most sensitive cell easily killed by irradiation with a laser diode at 775 nm by 2 J/cm2. The Melur SP 18 cell line needs 5 J/cm2 for the same effect. In both cases the decay of overliving cells obeys apparently the simple exponential law. In the melanotic SkMel 25 an overshoting plateau at low energy fluence was observed signalizing a metastatic potency induced by PDT. This is documented by a series of photographs. In principle, photosensitizing drugs with absorption maxima in the far red region are suitable to treat malignant melanoma with high efficiency. A method has to be developed to overcome PDT stimulation at low energy densities in melanotic melanoma.

Paper Details

Date Published: 18 June 1993
PDF: 10 pages
Proc. SPIE 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II, (18 June 1993); doi: 10.1117/12.146301
Show Author Affiliations
Joerg G. Moser, Heinrich-Heine Univ. (Germany)


Published in SPIE Proceedings Vol. 1881:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II
Thomas J. Dougherty, Editor(s)

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