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Proceedings Paper

Porphyrins as radiosensitizers in 60Co-irradiated E. ascites tumor cells: possibility to combine with PDT
Author(s): Zivile Luksiene; B. Juodka
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Paper Abstract

Efficiency of Ehrlich ascites cells radiosensitization by porphyrins is a function of irradiation dose. The maximal radiosensitization was reached at the dose--2Gy. Moreover, efficiency of cell radiosensitization depends on extracellular porphyrins concentration Hematoporphyrin (HP) and hemaporphyrin dimethylether (HPde) have different radiosensitizing effect on cells. One of the reasons of such phenomenon may be the different degree of hydrofobicity of those porphyrins. The studies of intracellular porphyrins concentration show that they differ in the case of HP and HPde in the same order as cell radiosensitization efficiencies.

Paper Details

Date Published: 18 June 1993
PDF: 9 pages
Proc. SPIE 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II, (18 June 1993); doi: 10.1117/12.146296
Show Author Affiliations
Zivile Luksiene, Lithuanian Oncology Ctr. (Lithuania)
B. Juodka, Vilnius Univ. (Lithuania)


Published in SPIE Proceedings Vol. 1881:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II
Thomas J. Dougherty, Editor(s)

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