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Proceedings Paper

Effect of photodynamic therapy on mouse platelets
Author(s): Chuannong Zhou; Shunji Chi; Jinsheng Deng; Hua Zhang; Junlin Liang; Xian-wen Ha
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Paper Abstract

Normal mice received hematoporphyrin derivative (HpD) i.v. prior to red light irradiation and the platelet-rich plasma was prepared and irradiated by red light. The platelets were processed for EM examination and stereological analysis. It was shown the 16 hrs after irradiation almost all platelets were necrotized; 8 hours after irradiation about one fourth of the platelets were necrotized and the remaining were considerably damaged. Immediately after irradiation a small number of platelets became necrotic and most other platelets were swollen and deformated, showing significantly increased mean area, perimeter and short axis, and mean cell volume and cell surface area. The findings indicate that platelets are highly sensitive to PDT action and can be directly and rapidly damaged by PDT even in the absence of vascular endothelial cells. The early platelet photoactivation may play an important role in the initiation of early vascular damage and microcirculatory alterations induced by PDT in vivo.

Paper Details

Date Published: 18 June 1993
PDF: 7 pages
Proc. SPIE 1881, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II, (18 June 1993); doi: 10.1117/12.146295
Show Author Affiliations
Chuannong Zhou, Chinese Academy of Medical Sciences (China)
Shunji Chi, Chinese Academy of Medical Sciences (China)
Jinsheng Deng, Chinese Academy of Medical Sciences (China)
Hua Zhang, Chinese Academy of Medical Sciences (China)
Junlin Liang, Chinese Academy of Medical Sciences (China)
Xian-wen Ha, Chinese Academy of Medical Sciences (China)


Published in SPIE Proceedings Vol. 1881:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy II
Thomas J. Dougherty, Editor(s)

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