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Proceedings Paper

Lanthanide macrocyclic complexes, 'quantum dyes': optical properties and significance
Author(s): Lidia M. Vallarino; Patrick M. Harlow; Robert C. Leif
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Paper Abstract

Macrocylic complexes of the lanthanide (III) ions were functionalized to permit their attachment to antibodies, nucleic acid probes, and any other species capable of specific binding. The Eu(III) complex was found to possess a combination of properties (water solubility, inertness to metal release, ligand-sensitized luminescence, reactive peripheral functionalities) that make it suitable as a luminescent marker for bio-substrates. Its coupling to avidin was achieved, and the properties of the resulting conjugate were investigated.

Paper Details

Date Published: 18 May 1993
PDF: 10 pages
Proc. SPIE 1885, Advances in Fluorescence Sensing Technology, (18 May 1993); doi: 10.1117/12.144724
Show Author Affiliations
Lidia M. Vallarino, Virginia Commonwealth Univ. (United States)
Patrick M. Harlow, Virginia Commonwealth Univ. (United States)
Robert C. Leif, Coulter Corp. (United States)

Published in SPIE Proceedings Vol. 1885:
Advances in Fluorescence Sensing Technology
Joseph R. Lakowicz; Richard B. Thompson, Editor(s)

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