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Proceedings Paper

Evanescent-wave infrared fiber optic biosensor
Author(s): L. Pierre de Rochemont; Nancy W. Downer; Timothy E. May; H. Gilbert Smith; Carlton E. Oakes; Marc E. Ertan-Lamontagne
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Paper Abstract

An infrared fiber-optic neurotoxin biosensor was constructed by applying a biologically active cladding to the core of an infrared transmitting chalcogenide fiber. Binding of the surface bound receptor protein was monitored by performing infrared difference spectroscopy on the fiber-optic probe before and after its exposure to various concentrations of neurotoxin in solution. Signals measuring conformational change(s) as a result of these interactions are observed to saturate in agreement with established biochemical kinetics for the receptor. Fiber-optic components are shown to be much more sensitive than bulk optical components in performing these measurements.

Paper Details

Date Published: 30 April 1993
PDF: 11 pages
Proc. SPIE 1796, Chemical, Biochemical, and Environmental Fiber Sensors IV, (30 April 1993); doi: 10.1117/12.143548
Show Author Affiliations
L. Pierre de Rochemont, Radiation Monitoring Devices, Inc. (United States)
Nancy W. Downer, TSI Corp. (United States)
Timothy E. May, Nicolet Instruments Corp. (United States)
H. Gilbert Smith, TSI Corp. (United States)
Carlton E. Oakes, Radiation Monitoring Devices, Inc. (United States)
Marc E. Ertan-Lamontagne, Univ. of New Hampshire (United States)


Published in SPIE Proceedings Vol. 1796:
Chemical, Biochemical, and Environmental Fiber Sensors IV
Robert A. Lieberman, Editor(s)

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