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Proceedings Paper

Determination of platinum in blood and urine as a tool for the biological monitoring of internal exposure
Author(s): Karl Heinz Schaller; Juergen Angerer; Friedrich Alt; Juergen Messerschmidt; Andreas Weber
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Paper Abstract

The increased industrial use of platinum has led to a growing need for the determination of platinum levels in biological materials. Concern about the release of toxic material from catalytic converters in motor vehicles in the environment and about occupational platinum exposure of employees working in the assembly of motor vehicle catalyzers and recycling led us to establish background and internal exposure levels in human body fluids. The development of an analytical procedure, based on adsorptive voltammetry with an extremely high power of detection (2 pg Pt absolute) for the determination in body fluids made population studies reliable and practicable. The methods are described and the reliability criteria are presented. For 13 not occupationally exposed persons the platinum levels ranged in urine from <EQ 0,4 - 14,3 ng/l, in whole blood from <EQ 0,8 - 6,9 ng/l and in plasma from <EQ 0,8 - 6,9 ng/l. Employees (N equals 40) engaged in various workplaces with the manufacturing and recycling of platinum containing catalysts showed much higher platinum levels ranging from 10 - 2900 ng/l urine, 2 - 180 ng/l blood and 4 - 280 ng/l plasma. This was in agreement with the external exposure levels, which exceeded the German MAK value of 2 (mu) g/m3. Platinum concentrations in human biological materials seem to be suitable as internal exposure indicators.

Paper Details

Date Published: 9 March 1993
PDF: 7 pages
Proc. SPIE 1716, International Conference on Monitoring of Toxic Chemicals and Biomarkers, (9 March 1993); doi: 10.1117/12.140286
Show Author Affiliations
Karl Heinz Schaller, Univ. Erlangen-Nuernberg (Germany)
Juergen Angerer, Univ. Erlangen-Nuernberg (Germany)
Friedrich Alt, Institute of Spectrochemistry and Applied Spectroscopy (Germany)
Juergen Messerschmidt, Institute of Spectrochemistry and Applied Spectroscopy (Germany)
Andreas Weber, Univ. Erlangen-Nuernberg (Germany)

Published in SPIE Proceedings Vol. 1716:
International Conference on Monitoring of Toxic Chemicals and Biomarkers

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