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Proceedings Paper

Studies of the mutagenic effects of styrene to man: conclusions for the surveillance of styrene-exposed workers
Author(s): Roland Rothe; P. Schmidt; T. Grummt; H. J. Grummt; N. Kersten; Hans-Juergen Weigmann
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Paper Abstract

One hundred fifty-six styrene-exposed workers had a fourfold higher rate of chromosome aberrations in peripheral lymphocytes than the control persons. The parameters of clinical chemistry (liver, kidney, and blood) remained in the normal range. Further analyses of the data of this study revealed no connections of the degree of effects in clinical chemistry and the exposure level. But a connection exists to the duration of exposure (3 - 26 years): in the comparison of the mean values (all mean values within the normal range) significant differences were found between long-term exposed workers (more than ten years) and control persons. In the higher age groups (above 45 years) also the GAP-rate differences are more pronounced. Seventy percent of the TWA-values were found to be below 85 mg/m3; the arithmetic mean of the TWA-values 72,3 mg/m3. A health surveillance program to styrene-exposed workers is to be reviewed (clinical chemistry and genetic effects). Proposals concerning both problems are presented.

Paper Details

Date Published: 9 March 1993
PDF: 12 pages
Proc. SPIE 1716, International Conference on Monitoring of Toxic Chemicals and Biomarkers, (9 March 1993); doi: 10.1117/12.140278
Show Author Affiliations
Roland Rothe, Federal Institute of Occupational Health (Germany)
P. Schmidt, Federal Institute of Occupational Health (Germany)
T. Grummt, Institute for Hygiene and Microbiology (Germany)
H. J. Grummt, Institute for Hygiene and Microbiology (Germany)
N. Kersten, Federal Institute of Occupational Health (Germany)
Hans-Juergen Weigmann, Federal Institute of Occupational Health (Germany)


Published in SPIE Proceedings Vol. 1716:
International Conference on Monitoring of Toxic Chemicals and Biomarkers

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