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Proceedings Paper

Use of biomarkers to assess environmental health
Author(s): Lee R. Shugart; Richard S. Halbrook
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Paper Abstract

Environmental pollution has received considerable coverage in the news media. This has stimulated public interest and generated pressure on private industries and governmental agencies to take corrective action. Because the environmental issues have at times been presented in a simplistic and sensational manner, the corrective response by regulatory agencies and industry is often cursory and narrow. An approach, using biomarkers (biological responses), for assessing the biological and ecological significance of contaminants present in the environment is described. Living organisms integrate exposure to contaminants in their environment and respond in some measurable and predictable way. Responses are observed at several levels of biological organization from the biomolecular level, where pollutants can cause damage to critical cellular macromolecules and elicit defensive strategies such as detoxication and repair mechanisms, to the organismal level, where severe disturbances are manifested as impairment in growth, reproduction, developmental abnormalities, or decreased survival. Biomarkers can provide, not only evidence of exposure to a broad spectrum of anthropogenic chemicals, but also a temporally-integrated measure of bioavailable contaminant levels. A suite of biomarkers are evaluated over time to determine the magnitude of the problem and possible consequences. Pragmatically, the biomarker approach will help to assess the health of the environment, and, in addition, will enable scientists to defend the advice they provide concerning environmental issues.

Paper Details

Date Published: 9 March 1993
PDF: 6 pages
Proc. SPIE 1716, International Conference on Monitoring of Toxic Chemicals and Biomarkers, (9 March 1993); doi: 10.1117/12.140255
Show Author Affiliations
Lee R. Shugart, Oak Ridge National Lab. (United States)
Richard S. Halbrook, Oak Ridge National Lab. (United States)

Published in SPIE Proceedings Vol. 1716:
International Conference on Monitoring of Toxic Chemicals and Biomarkers
Tuan Vo-Dinh; Karl Cammann, Editor(s)

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