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Proceedings Paper

Problem solving in pharmaceutical production using scanning infrared microprobe analysis
Author(s): John A. Reffner
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Paper Abstract

The infrared microprobe is a powerful analytical technology for problem-solving in the pharmaceutical industry, providing the problem-solver with a tool for analyzing organic and many inorganic materials at the microscopic level. While the most obvious application of the infrared microprobe is the analysis of contaminants and product defects, SIRM also provides a way of monitoring solid-state forms, states of hydration or solvation, identities of inclusions in crystals, polymorphism, and quantitative analysis of materials. Analyzing and monitoring packaging materials (which are often multi-layered polymer materials) is another major area of SIRM application. The instrumentation and applications for SIRM are presented.

Paper Details

Date Published: 14 August 1992
PDF: 5 pages
Proc. SPIE 1681, Optically Based Methods for Process Analysis, (14 August 1992); doi: 10.1117/12.137753
Show Author Affiliations
John A. Reffner, Spectra-Tech, Inc. (United States)


Published in SPIE Proceedings Vol. 1681:
Optically Based Methods for Process Analysis
David S. Bomse; Harry Brittain; Stuart Farquharson; Jeremy M. Lerner; Alan J. Rein; Cary Sohl; Terry R. Todd; Lois Weyer, Editor(s)

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