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Proceedings Paper

Determination of transesterification reaction endpoint using NIR spectroscopy
Author(s): Wayne D. Mockel; Mark P. Thomas
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Paper Abstract

An analytical method based on fiber optic near infrared spectroscopy (NIR) and partial least squares data analysis (PLS) was developed to monitor a reaction in which a methyl ester is transesterified with polyethylene glycol 300 (PEG 300) to give the corresponding PEG 300 ester and methanol. A series of multivariant modeling techniques which predict the transesterification reaction end point by monitoring the PEG 300 content were evaluated. The models were developed by making a series of transesterification reactions, collecting grab samples, analyzing them by using the NIR spectrophotometer and liquid chromatography (HPLC) to construct a training and validation set consisting of 50 data points. The models were evaluated in the laboratory setting and the PLS model was used in a pilot plant to predict the reaction end point. Use of the NIR modeling system in the pilot plant led to reduced reaction times and a concomitant rise in product quality. A purged NEMA enclosure was manufactured and was used to house the NIR instrumentation in the pilot plant setting.

Paper Details

Date Published: 14 August 1992
PDF: 11 pages
Proc. SPIE 1681, Optically Based Methods for Process Analysis, (14 August 1992); doi: 10.1117/12.137739
Show Author Affiliations
Wayne D. Mockel, Ciba-Geigy Corp. (United States)
Mark P. Thomas, Ciba-Geigy Corp. (United States)

Published in SPIE Proceedings Vol. 1681:
Optically Based Methods for Process Analysis
David S. Bomse; Harry Brittain; Stuart Farquharson; Jeremy M. Lerner; Alan J. Rein; Cary Sohl; Terry R. Todd; Lois Weyer, Editor(s)

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