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Proceedings Paper

Photochemical effects of chloroaluminum-sulfonated phthalocyanine in arteries with intimal hyperplasia
Author(s): Paolo Ortu; Glenn M. LaMuraglia; Walter Gregory Roberts; Kevin T. Schomacker; Thomas F. Deutsch; Thomas J. Flotte; Tayyaba Hasan
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Paper Abstract

The present study uses photodynamic therapy (PDT) for the treatment of IH in the rat carotid artery model. PDT is a relatively new cancer treatment technique which utilizes light-activated photosensitizers (PS) to produce injury to targeted cells. PS have no cytotoxic effects unless they are activated by the appropriate wavelength of light. Upon absorption of a photon, the activated PS can either by directly cytotoxic or give rise to cytotoxic oxygen species, commonly singlet oxygen, via energy transfer to the ground state molecular oxygen. Singlet oxygen then becomes the mediator of cellular injury by affecting cellular membranes and subcellular organelles.

Paper Details

Date Published: 7 August 1992
PDF: 7 pages
Proc. SPIE 1646, Laser-Tissue Interaction III, (7 August 1992); doi: 10.1117/12.137458
Show Author Affiliations
Paolo Ortu, Massachusetts General Hospital and Wellman Labs. of Photomedicine (Albania)
Glenn M. LaMuraglia, Massachusetts General Hospital and Wellman Labs. of Photomedicine (United States)
Walter Gregory Roberts, Massachusetts General Hospital and Wellman Labs. of Photomedicine (United States)
Kevin T. Schomacker, Massachusetts General Hospital and Wellman Labs. of Photomedicine (United States)
Thomas F. Deutsch, Massachusetts General Hospital and Wellman Labs. of Photomedicine (United States)
Thomas J. Flotte, Massachusetts General Hospital and Wellman Labs. of Photomedicine (United States)
Tayyaba Hasan, Massachusetts General Hospital and Wellman Labs. of Photomedicine (United States)


Published in SPIE Proceedings Vol. 1646:
Laser-Tissue Interaction III
Steven L. Jacques, Editor(s)

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