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Proceedings Paper

Artificial cornea: cellular ingrowth and transparency of an expanded polytetrafluoroethylene
Author(s): Jean-Marc Legeais; Gilles Renard; Jean-Marie A. Parel; Gabriel Simon; Yves Pouliquen
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Paper Abstract

The development of a matrix with high cell adhesion and ingrowth rates is of importance for artificial cornea. The design of such artificial matrices requires understanding of cellular system colonization processes. After lamellar implementation the more impermeable the material, the larger the diameter and the more anterior placement, the more likely it is that the anterior stroma will starve and become necrotic. One approach to this problem is fenestration or open porosity of the material. Modifications in the thickness, pore size, and their geometric orientation of an expanded polytetrafluorethylene could modify the cellular ingrowth rate. Immunohistochemical study with the monoclonal antibodies AE5 showed normal epithelial differentiation over the polymer. The material in first white opaque became progressively transparent after colonization and demonstrated that an opaque hydrophobic material may become transparent and completely wettable with very low perturbation of the flow through the cornea.

Paper Details

Date Published: 14 August 1992
PDF: 7 pages
Proc. SPIE 1644, Ophthalmic Technologies II, (14 August 1992); doi: 10.1117/12.137412
Show Author Affiliations
Jean-Marc Legeais, INSERM (France)
Gilles Renard, INSERM (France)
Jean-Marie A. Parel, Univ. of Miami School of Medicine (United States)
Gabriel Simon, Univ. of Miami School of Medicine (United States)
Yves Pouliquen, INSERM (France)


Published in SPIE Proceedings Vol. 1644:
Ophthalmic Technologies II
Jean-Marie Parel, Editor(s)

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