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Proceedings Paper

Acute and chronic response of articular cartilage to Ho:YAG laser irradiation
Author(s): Kenneth B. Trauner; Norman S. Nishioka; Thomas J. Flotte; Dinesh K. Patel
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Paper Abstract

A Ho:YAG laser system operating at a wavelength of 2.1 microns has recently been introduced for use in arthroscopic surgery. The acceptability of this new tool will be determined not only by its ability to resect tissue, but also by its long term effects on articular surfaces. In order to investigate these issues further, we performed two studies to evaluate the acute and chronic effects of the laser on cartilaginous tissue. We evaluated the acute, in vitro effects of 2.1 micron laser irradiation on articular and fibrocartilage. This included the measurement of ablation efficiency, ablation threshold and thermal damage in both meniscus and articular cartilage. To document the chronic effects on articular cartilage in vivo, we next performed a ten week healing study. Eight sheep weighing 30 - 40 kg underwent bilateral arthrotomy procedures. Multiple full thickness and partial thickness defects were created. Animals were sacrificed at 0, 2, 4, and 10 weeks. The healing study demonstrated: (1) no healing of full or partial thickness defects at 10 weeks with hyaline cartilage; (2) fibrocartilaginous granulation tissue filling full thickness defects at two and four weeks, but no longer evident at ten weeks; (3) chondrocyte necrosis extending to greater than 900 microns distal to ablation craters at four weeks with no evidence of repair at later dates; and (4) chondrocyte hyperplasia at the borders of the damage zone at two weeks but no longer evident at later sacrifice dates.

Paper Details

Date Published: 1 June 1992
PDF: 7 pages
Proc. SPIE 1643, Laser Surgery: Advanced Characterization, Therapeutics, and Systems III, (1 June 1992); doi: 10.1117/12.137367
Show Author Affiliations
Kenneth B. Trauner, Univ. of California/Davis (United States)
Norman S. Nishioka, Massachusetts General Hospital and Wellman Labs. of Photomedicine (United States)
Thomas J. Flotte, Massachusetts General Hospital and Wellman Labs. of Photomedicine (United States)
Dinesh K. Patel, Massachusetts General Hospital and Wellman Labs. of Photomedicine (United States)


Published in SPIE Proceedings Vol. 1643:
Laser Surgery: Advanced Characterization, Therapeutics, and Systems III
R. Rox Anderson, Editor(s)

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