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Proceedings Paper

Tissue welding with virus-sterilized human cryoprecipitate
Author(s): Matthew R. Williams; Christian I. Fras; Richard D. Moscarelli; Steven K. Libutti; Mehmet Cengiz Oz; Lawrence S. Bass; Adrianne J. Setton; Murat Kaynar; Roman Nowygrod; Michael R. Treat
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Paper Abstract

Clinical use of laser tissue soldering with cryoprecipitate has been delayed by the fear of infecting recipients with donor viral products. Solvent-Detergent (S/D) treatment of human plasma is a technique for disrupting membrane enveloped viruses and rendering them noninfectious. Dual 6 cm incisions were created on the dorsum of nine rats and closed with either standard skin staples of with laser activated S/D cryoprecipitate. The animals were sacrificed at one of three time periods: 0, 2, and 4 days. The use of the laser tissue solder significantly improved tensile strength over standard skin closures at all time periods. Deactivation of viral particles during preparation of cryoprecipitate does not reduce the utility of this material as a solder during laser bonding. Reduced infectivity of S/D prepared products enhances their clinical utility.

Paper Details

Date Published: 1 June 1992
PDF: 4 pages
Proc. SPIE 1643, Laser Surgery: Advanced Characterization, Therapeutics, and Systems III, (1 June 1992); doi: 10.1117/12.137351
Show Author Affiliations
Matthew R. Williams, Columbia Univ. College of Physicians and Surgeons (United States)
Christian I. Fras, Columbia Univ. College of Physicians and Surgeons (United States)
Richard D. Moscarelli, Columbia Univ. College of Physicians and Surgeons (United States)
Steven K. Libutti, Columbia Univ. College of Physicians and Surgeons (United States)
Mehmet Cengiz Oz, Columbia Univ. College of Physicians and Surgeons (United States)
Lawrence S. Bass, Columbia Univ. College of Physicians and Surgeons (United States)
Adrianne J. Setton, Columbia Univ. College of Physicians and Surgeons (United States)
Murat Kaynar, Columbia Univ. College of Physicians and Surgeons (United States)
Roman Nowygrod, Columbia Univ. College of Physicians and Surgeons (United States)
Michael R. Treat, Columbia Univ. College of Physicians and Surgeons (United States)


Published in SPIE Proceedings Vol. 1643:
Laser Surgery: Advanced Characterization, Therapeutics, and Systems III
R. Rox Anderson, Editor(s)

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