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Proceedings Paper

Treatment of spontaneously occurring veterinary tumors with photodynamic therapy
Author(s): Masoud Panjehpour; Alfred Legendre; Rick E. Sneed; Bergein F. Overholt
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Paper Abstract

Chloroaluminum phthalocyanine tetrasulfonate was administered intravenously (1.0 mg/kg) to client owned cats and a dog with spontaneously occurring squamous cell carcinoma of head and neck. Light was delivered 48 hours post injection of the photosensitizer. An argon- pumped dye-laser was used to illuminate the lesions with 675 nm light delivered through a microlens fiber and/or a cylindrical diffuser. The light dose was 100 J/cm2 superficially or 300 J/cm interstitially. Eleven photodynamic therapy treatments in seven cats and one dog were performed. Two cats received a second treatment in approximately sixty days after the initial treatment. The superficial dose of light was increased to 200 J/cm2 for the second treatment. While the longest follow-up is twelve months, the responses are encouraging. The dog had a complete response. Among the cats, three showed complete response, three showed partial response and one showed no response. One cat expired two days post treatment. It is early to evaluate the response in two cats that received second treatments. Photodynamic therapy with chloroaluminum phthalocyanine tetrasulfonate was effective in treating squamous cell carcinoma in pet animals.

Paper Details

Date Published: 1 June 1992
PDF: 6 pages
Proc. SPIE 1643, Laser Surgery: Advanced Characterization, Therapeutics, and Systems III, (1 June 1992); doi: 10.1117/12.137336
Show Author Affiliations
Masoud Panjehpour, Thompson Cancer Survival Ctr. and Univ. of Tennessee College of Veterinary Medicine (United States)
Alfred Legendre, Univ. of Tennessee College of Veterinary Medicine (United States)
Rick E. Sneed, Thompson Cancer Survival Ctr. (United States)
Bergein F. Overholt, Thompson Cancer Survival Ctr. and Univ. of Tennessee College of Veterinary Medicine (United States)


Published in SPIE Proceedings Vol. 1643:
Laser Surgery: Advanced Characterization, Therapeutics, and Systems III
R. Rox Anderson, Editor(s)

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