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Proceedings Paper

Transluminal angiomicroscopy of arterial thrombosis and thrombolysis
Author(s): Takanobu Tomaru; Yasumi Uchida; Fumitaka Nakamura; Atsuko Miwa; Koichiro Yamada; Tsuneaki Sugimoto
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Paper Abstract

To examine the process of microscopic changes during arterial thrombosis and thrombolysis a novel angiomicroscope (3 or 4 mm in diameter, magnification rate X 145) was introduced through a sheath into the right iliac artery of anesthetized dogs. A small portion of the luminal surface was mechanically damaged and processes of thrombogenesis were examined. Platelet aggregation on the damaged portion, fibrin thread growth on the exfoliated endothelium and naked subendothelial layers, trapping of red blood cells by fibrin networks, and gradual growth of mixed thrombi were observed. Following administration of prourokinase, or t-PA, dispersion of platelet aggregates and red blood cells, simulating sandstorm and gradual melting of fibrin, were also observed. The results indicate that detailed microscopic processes of thrombogenesis and thrombolysis can be observed percutaneously by angiomicroscopy.

Paper Details

Date Published: 28 August 1992
PDF: 4 pages
Proc. SPIE 1642, Diagnostic and Therapeutic Cardiovascular Interventions II, (28 August 1992); doi: 10.1117/12.137310
Show Author Affiliations
Takanobu Tomaru, Univ. of Tokyo (Japan)
Yasumi Uchida, Univ. of Tokyo (Japan)
Fumitaka Nakamura, Univ. of Tokyo (Japan)
Atsuko Miwa, Univ. of Tokyo (Japan)
Koichiro Yamada, Univ. of Tokyo (Japan)
Tsuneaki Sugimoto, Univ. of Tokyo (Japan)

Published in SPIE Proceedings Vol. 1642:
Diagnostic and Therapeutic Cardiovascular Interventions II
George S. Abela, Editor(s)

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