Share Email Print
cover

Proceedings Paper

Arterial healing response after angioplasty and its contributions to restenosis
Author(s): Cornelius Borst; Lieselotte van Erven; Evelyn Velema; Mark J. Post
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

Balloon angioplasty of coronary obstructions is limited by a 40% angiographic restenosis rate six months after the intervention. Myointimal hyperplasia is a major contributor to restenosis. In 77 normal rabbits we examined the question whether severe thermal interventional injury to the iliac artery wall would result in less myointimal hyperplasia than severe mechanical injury induced by balloon dilation. Eight weeks after percutaneous injury by electrical spark erosion, the metal laser probe, cw Nd:YAG laser energy through the sapphire contact probe, 90 degree(s)C RF heated balloon dilation, or standard balloon dilation the neointima thickness measured up to 380 micrometers . When thermally and mechanically damaged walls were compared, myointimal hyperplasia was similar. We conclude that in the normal rabbit the arterial wall healing response after any injury is neointima formation which is the vessel wall's expression of the general pattern of wound healing. It is inferred that alternative modes of injury in new recanalization techniques will lead to induced restenosis rates.

Paper Details

Date Published: 28 August 1992
PDF: 4 pages
Proc. SPIE 1642, Diagnostic and Therapeutic Cardiovascular Interventions II, (28 August 1992); doi: 10.1117/12.137308
Show Author Affiliations
Cornelius Borst, Univ. Hospital Utrecht (Netherlands)
Lieselotte van Erven, Univ. Hospital Utrecht (Netherlands)
Evelyn Velema, Univ. Hospital Utrecht (Netherlands)
Mark J. Post, Univ. Hospital Utrecht (Netherlands)


Published in SPIE Proceedings Vol. 1642:
Diagnostic and Therapeutic Cardiovascular Interventions II
George S. Abela, Editor(s)

© SPIE. Terms of Use
Back to Top