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Proceedings Paper

In-vivo holmium laser angioplasty
Author(s): Karl Konstantin Haase M.D.; Stefan Hassenstein M.D.; Hartmut Hanke M.D.; Sybille Hanke M.D.; Martin Oberhoff M.D.; Karl R. Karsch M.D.
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Paper Abstract

Holmium laser angioplasty was performed in the atheromatous carotid artery of 10 rabbits to evaluate this mid-infrared laser as an alternative energy source for angioplasty. An additional 10 rabbits served as a control group. The laser emitted light at a wavelength of 2120 nm with pulse durations of 150 microsecond(s) . The energy density was 17.5 J/cm2. Cross sections were analyzed in regard to laser specific injury 7 and 14 days following laser irradiation. Staining of (alpha) -actin was used to identify smooth muscle cells (SMC), and bromodesoxyuridine labeling was carried out to determine the extent of proliferating cells. Integrity of the lamina elastica interna fibers was disrupted in 6 of 10 animals. In all animals, loss of medial SMCs was observed 7 and 14 days after treatment. Quantification of SMCs undergoing DNA synthesis in the intima and media showed a significant increase of labelled cells following laser irradiation. This proliferative response resulted in a significant increase of intimal thickening after laser ablation.

Paper Details

Date Published: 28 August 1992
PDF: 8 pages
Proc. SPIE 1642, Diagnostic and Therapeutic Cardiovascular Interventions II, (28 August 1992); doi: 10.1117/12.137291
Show Author Affiliations
Karl Konstantin Haase M.D., Univ. of Tuebingen (Germany)
Stefan Hassenstein M.D., Univ. of Tuebingen (Germany)
Hartmut Hanke M.D., Univ. of Tuebingen (Germany)
Sybille Hanke M.D., Univ. of Tuebingen (Germany)
Martin Oberhoff M.D., Univ. of Tuebingen (Germany)
Karl R. Karsch M.D., Univ. of Tuebingen (Germany)

Published in SPIE Proceedings Vol. 1642:
Diagnostic and Therapeutic Cardiovascular Interventions II
George S. Abela M.D., Editor(s)

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