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Proceedings Paper

Dosimetry for photodynamic therapy of malignant tumors
Author(s): Lars Othar Svaasand
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Paper Abstract

The rationale of photodynamic therapy is based on the cytotoxic action of products generated by excited photosensitizers. Recent development has brought forward a series of promising photosensitizers ranging from hematoporphyrin derivative, various kinds of phthalocyanines and chlorins, to (delta) -aminolevulinic acid. The therapeutic efficacy is dependent on parameters such as tissue oxygenation, sensitizer distribution, drug clearance, optical irradiation, and exposure time. The general outline of a dosimetry model, which enables all these effects to be taken into account, is discussed.

Paper Details

Date Published: 5 March 1993
PDF: 13 pages
Proc. SPIE 1616, International Conference on Photodynamic Therapy and Laser Medicine, (5 March 1993); doi: 10.1117/12.137060
Show Author Affiliations
Lars Othar Svaasand, Univ. of Trondheim (Norway)

Published in SPIE Proceedings Vol. 1616:
International Conference on Photodynamic Therapy and Laser Medicine
Junheng Li M.D., Editor(s)

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