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Proceedings Paper

Depth of necrosis induced by photodynamic therapy with sulfonated aluminum phthalocyanine in S180 fibrosarcoma of mice
Author(s): Hong-Yu Yu; Rong-Chun Dong; Ji-Yao Chen; Huai-Xin Cai
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Paper Abstract

In view of explaining the results that AlSPC-PDT was more effective than HPD-PDT in destroying S180 fibrosarcoma (diameter: 0.5 - 0.8 cm; thickness: 0.4 - 0.7 cm) transplanted in white mice, the depth of necrosis of S180 sarcoma in mice in AlSPC-PDT was studied, compared with it in HPD-PDT. Two kinds of HPD were chosen as the control photosensitizers of AlSPC: Photofrin I (PI), and Photosensitizing drug-007 (PSD-007). The experimental tumors in mice were chosen with longitudinal diameters in the range of 0.8 - 1.0 cm and thickness in the range of 0.7 - 1.0 cm. A photosensitizer dose of 10 mg/kg was given (iv) for PI-PDT, PSD-007-PDT, and AlSPC-PDT. The dose of exposure light (600 - 750 nm) was 180 J/cm2. The experimental mice were killed 48 h after PDT to get the tumor necrotic depth. The depth was 0.55 +/- 0.14 cm (0.30 - 0.85 cm) in the AlSPC-PDT group, 0.35 +/- 0.12 cm (0.20 - 0.55 cm) in the PI-PDT group, and 0.36 +/- 0.11 cm (0.20 - 0.50 cm) in the PSD-007-PDT group. These differences may be due to the differences of the dyes' light absorbance spectra. AlSPC's main absorbance peak is at 675 nm and HPD's is around 400 nm with a smaller peak at 630 nm. The penetration of 675 nm light through biologic tissue is deeper than that of 400 nm light and 630 nm light.

Paper Details

Date Published: 5 March 1993
PDF: 6 pages
Proc. SPIE 1616, International Conference on Photodynamic Therapy and Laser Medicine, (5 March 1993); doi: 10.1117/12.137033
Show Author Affiliations
Hong-Yu Yu, Second Military Medical Univ. (China)
Rong-Chun Dong, Second Military Medical Univ. (China)
Ji-Yao Chen, Fudan Univ. (China)
Huai-Xin Cai, Fudan Univ. (China)

Published in SPIE Proceedings Vol. 1616:
International Conference on Photodynamic Therapy and Laser Medicine
Junheng Li, Editor(s)

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