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Proceedings Paper

Photodynamic therapy with chlorin e6 dose-effect relation on an inoculated rat tumor model
Author(s): Ivan N. Zhuravkin; Gennady Kostenich; G. P. Gurinovich; Edvard A. Zhavrid
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Paper Abstract

The antitumor effect of photodynamic treatment with chlorin e6 was studied. A transplantable rat tumor (sarcoma M-1) was irradiated by krypton ion laser light after chlorin e6 injection at different doses of photoradiation (22.5 - 180 J/cm2) and photosensitizer (1 - 10 mg/kg). The time interval between chlorin e6 intravenous injection and photoradiation was varied from 15 min to 72 hours. Tumor growth inhibition coefficient (TGIC), tumor regression rate, and cure of animals were used as antitumor criteria of photodynamic treatment. It was found that the antitumor effect of photodynamic therapy was in direct relationship to the chlorin e6 dose and light energy exposure value and in the inverse one to the time interval between photosensitizer injection and photoradiation.

Paper Details

Date Published: 5 March 1993
PDF: 18 pages
Proc. SPIE 1616, International Conference on Photodynamic Therapy and Laser Medicine, (5 March 1993); doi: 10.1117/12.137030
Show Author Affiliations
Ivan N. Zhuravkin, Institute of Oncology and Medical Radiology (Belarus)
Gennady Kostenich, Institute of Oncology and Medical Radiology (Belarus)
G. P. Gurinovich, Institute of Physics (Belarus)
Edvard A. Zhavrid, Institute of Oncology and Medical Radiology (Belarus)


Published in SPIE Proceedings Vol. 1616:
International Conference on Photodynamic Therapy and Laser Medicine

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