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Proceedings Paper

Photodynamic effect of chlorophyll derivative with pulsed copper-vapor laser on human rectal carcinoma in vitro
Author(s): Li-Song Teng; Shu Zheng; Jin-Min Wu; Hai Yu; Zhao-Min Cheng
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Paper Abstract

In the present study, the effects of a newly developed photosensitizer chrolophyll derivative (CPD4) from Chinese Medicine Cansha (silkworm excrement) with pulsed copper vapor laser and pumped-dye laser (510, 578, 630, and 670 nm wavelength) on human rectal cancer cell line HR8348 was investigated. Hematoporphyrin derivative (YHPD) was used as a positive control. The relationship between CPD4 dose, the laser wavelength, and laser energy was explored. The MTT rapid colorimetric assay was used as a measuring indicator of photodynamic cytotoxicity and compared with 3H-thymidine incorporation assay and colony-forming assay. The photodynamic sensitivity of different cell lines was observed. The results showed that CPD4-induced HR8348 cells irradiated with pulsed copper vapor laser displayed a markedly photodynamic effect.

Paper Details

Date Published: 5 March 1993
PDF: 7 pages
Proc. SPIE 1616, International Conference on Photodynamic Therapy and Laser Medicine, (5 March 1993); doi: 10.1117/12.137029
Show Author Affiliations
Li-Song Teng, Zhejiang Medical Univ. (China)
Shu Zheng, Zhejiang Medical Univ. (China)
Jin-Min Wu, Zhejiang Medical Univ. (China)
Hai Yu, Zhejiang Medical Univ. (China)
Zhao-Min Cheng, Zhejiang Medical Univ. (China)

Published in SPIE Proceedings Vol. 1616:
International Conference on Photodynamic Therapy and Laser Medicine
Junheng Li M.D., Editor(s)

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