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Trial of photodynamic therapy for the treatment of tumors of the skin, head, and neck, and the results of an experimental study to determine the interrelationships between the tissue effects of ioni
Author(s): John A. S. Carruth; J. M. Barrett; D. W.H. Barnes; R. B. Buchanan; J. M. Sansom
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Paper Abstract

Photodynamic therapy (PDT) utilizes a tumor-localizing photo-sensitive substance which, when activated by light of an appropriate wavelength, releases cytotoxic substances causing destruction of the malignant tumor with preservation of surrounding normal tissues. In this technique the only drug/light combination which has been used regularly is that of hematoporphyrin derivative (HPD) and red light at a wavelength of 630 nanometers usually produced by a dye or gold vapor laser. This paper describes the results of a pilot/feasibility study using this technique to treat superficial tumors of the skin and head and neck carried out in Southampton between 1983 and 1989. Ethical permission was obtained to treat only patients who had failed all other appropriate treatment modalities and for whom there was no practical alternative therapy. It became apparent that, particularly in the treatment of tumors of the head and neck, PDT would be used as one of the arms in multi-modality treatment programs replacing chemotherapy in established protocols. It was considered essential, therefore, to undertake an experimental study to determine the interrelationship between photodynamic therapy and ionizing radiation and particularly to show that PDT does not have any adverse effects on the healing following radiation therapy.

Paper Details

Date Published: 5 March 1993
PDF: 6 pages
Proc. SPIE 1616, International Conference on Photodynamic Therapy and Laser Medicine, (5 March 1993); doi: 10.1117/12.137027
Show Author Affiliations
John A. S. Carruth, Southampton Univ. Hospitals and Medical Research Council (United Kingdom)
J. M. Barrett, Southampton Univ. Hospitals and Medical Research Council (United Kingdom)
D. W.H. Barnes, Southampton Univ. Hospitals and Medical Research Council (United Kingdom)
R. B. Buchanan, Southampton Univ. Hospitals and Medical Research Council (United Kingdom)
J. M. Sansom, Southampton Univ. Hospitals and Medical Research Council (United Kingdom)


Published in SPIE Proceedings Vol. 1616:
International Conference on Photodynamic Therapy and Laser Medicine

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