Share Email Print
cover

Proceedings Paper

Study on energy density of gold-vapor laser and necrosis depth of mouse malignant tumor (S180)
Author(s): Yong Guo; Ze-shi Wang; Yonghua Yang; Yongjiang Wang
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

Gold-vapor laser glass type is a new laser for photodynamic therapy (PDT). Its chief characteristics are pulse type, 6000 - 7000 Hz of frequency, 627.8 nm in wavelength, 3 - 4 watts output, etc. By changing laser energy density, we noticed changes of necrosis depth and surface temperature. The results show that the depth of groups of 500, 1000, 1500, and 2000 Jol/cm2 were 0.62 +/- 0.21, 0.72 +/- 0.05, 0.97 +/- 0.10, and 1.56 +/- 0.13 cm (p < 0.05), respectively. This study indicates that the pulse laser energy density should be larger than that of a continuant one in PDT, thus photodynamic effect may be improved in the clinic. The surface tumor temperature was changed during the treatment, reaching as high as 39.13 degree(s)C, 43.78 degree(s)C, 44.16 degree(s)C, and 43.5 degree(s)C in different groups. This paper also discusses the coordinated effects of hyperthermia and photodynamic therapy.

Paper Details

Date Published: 5 March 1993
PDF: 6 pages
Proc. SPIE 1616, International Conference on Photodynamic Therapy and Laser Medicine, (5 March 1993); doi: 10.1117/12.137025
Show Author Affiliations
Yong Guo, Zhejiang Hospital of Traditional Chinese Medicine (China)
Ze-shi Wang, Zhejiang Hospital of Traditional Chinese Medicine (China)
Yonghua Yang, Zhejiang Hospital of Traditional Chinese Medicine (China)
Yongjiang Wang, Zhejiang Univ. (United States)


Published in SPIE Proceedings Vol. 1616:
International Conference on Photodynamic Therapy and Laser Medicine
Junheng Li, Editor(s)

© SPIE. Terms of Use
Back to Top