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Proceedings Paper

New target for laser-hypocrellin A photosensitization: cell membrane DNA
Author(s): En-Hua Cao; Long-gui Wang; Shu-min Xin
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Paper Abstract

Hypocrellin A (HC-A) isolated from Hypocrella Membrane Sacc, a derivative of 3,10-dihydroxy-4, 9-peryleneguinone, is a new effective photosensitizer. Treatment of the CESS cell with 20 (mu) g per ml of HC-A plus laser (532 nm) radiation led to the formation of DNA single strand break. The number of single strand breaks for cell membrane DNA was approximately 2.5 times that of nuclear DNA. Treatment of the CESS cell with HC-A plus laser radiation reduced the cell DNA binding capacity by 59%. It is shown that cell membrane DNA is also a target for HC-A photosensitization.

Paper Details

Date Published: 5 March 1993
PDF: 6 pages
Proc. SPIE 1616, International Conference on Photodynamic Therapy and Laser Medicine, (5 March 1993); doi: 10.1117/12.137024
Show Author Affiliations
En-Hua Cao, Institute of Biophysics (China)
Long-gui Wang, Institute of Materia Medica (China)
Shu-min Xin, Institute of Biophysics (China)

Published in SPIE Proceedings Vol. 1616:
International Conference on Photodynamic Therapy and Laser Medicine

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