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Proceedings Paper

Observations of the incidence of metastasis following laser hyperthermia in combination with chemotherapy, PDT, and excision
Author(s): Mianjing Wang; Menglin Gao; Jin Gao; Kexun Xue; Zuyan Xu; Jingyuan Zhang; Qongru Li; Zifan Geng; Zhuo Gong; Qing Ye; Pei Gu; Jing-Lian Xao
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Paper Abstract

Our early observations have confirmed that laser hyperthermia or PDT alone does not promote the tumor metastasis. In order to evaluate the combined effect of local tumor laser hyperthermia on the distant metastasis, transplantable forestomach carcinoma (Fc) in 615 line mice was treated by Nd:YAG laser hyperthermia (45 degree(s)C/20 min) combined with PDT (HpD 5 mg/kg, 480 J/cm2, 20 min), chemotherapy (Cyclophosphamide 28.8 mg/kg) and excision, respectively. The results show that (1) the tumor growth inhibition by various treatment was significant compared with a control group; (2) no statistics different in metastasis rate were observed in laser hyperthermia combined with PDT, chemotherapy, or scalpel excision separately. It is suggested that laser hyperthermia combined with PDT, chemotherapy, or excision does not increase the incidence of the tumor metastasis.

Paper Details

Date Published: 5 March 1993
PDF: 4 pages
Proc. SPIE 1616, International Conference on Photodynamic Therapy and Laser Medicine, (5 March 1993); doi: 10.1117/12.136997
Show Author Affiliations
Mianjing Wang, Peking Union Medical College Hospital (China)
Menglin Gao, Peking Union Medical College Hospital (China)
Jin Gao, Institute of Basic Medical Sciences (China)
Kexun Xue, Institute of Basic Medical Sciences (China)
Zuyan Xu, Institute of Physics (China)
Jingyuan Zhang, Univ. of Science and Technology (China)
Qongru Li, Peking Union Medical College Hospital (China)
Zifan Geng, Univ. of Polytechnology (China)
Zhuo Gong, Peking Union Medical College Hospital (China)
Qing Ye, Peking Union Medical College Hospital (China)
Pei Gu, Institute of Basic Medical Sciences (China)
Jing-Lian Xao, Peking Union Medical College Hospital (China)


Published in SPIE Proceedings Vol. 1616:
International Conference on Photodynamic Therapy and Laser Medicine

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