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Proceedings Paper

Antitumor therapeutic efficacy of photoactivated phthalocyanines ZnS4PC and AlS2PC in tumor-bearing mice
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Paper Abstract

The photosensitizer of choice in photodynamic therapy (PDT) is the hematoporphyrin derivative (Hpd). However, Hpd has many characteristics which make it less than an ideal photosensitizer. The sulfonated phthalocyanines represent a new group of interesting compounds that have a strong absorption in the red part of the spectrum at 675 nm. In our laboratory we compare the efficacy of two phthalocyanines, the zincum tetrasulfonated (ZnS4Pc) and the aluminum disulfonated (AlS2Pc), on a murine tumor. Mice bearing MS-2 fibrosarcoma were treated with 5 or 25 mg/kg of ZnS4Pc or AlS2Pc and then the tumor mass was exposed to a laser light (100 mW for 10'). The results show that the treatment with AlS2Pc is significantly more therapeutically active in respect to the treatment with the same dose of ZnS4Pc. Moreover, resistance to rechallenge with the MS-2 tumor was evidenced by surviving animals. Studies are in progress with other murine tumors with different biological properties.

Paper Details

Date Published: 5 March 1993
PDF: 6 pages
Proc. SPIE 1616, International Conference on Photodynamic Therapy and Laser Medicine, (5 March 1993); doi: 10.1117/12.136987
Show Author Affiliations
Gianfranco L. Canti, Univ. of Milan (Italy)
Rinaldo Cubeddu, Centro di Elettronica Quantistica e Strumentazione Elettronica/CNR (Italy)
Paola Taroni, Centro di Elettronica Quantistica e Strumentazione Elettronica/CNR (Italy)
Gianluca Valentini, Centro di Elettronica Quantistica e Strumentazione Elettronica/CNR (Italy)


Published in SPIE Proceedings Vol. 1616:
International Conference on Photodynamic Therapy and Laser Medicine

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