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Proceedings Paper

In vivo three-dimensional optical coherence tomography and multiphoton microscopy in a mouse model of ovarian neoplasia
Author(s): Jennifer M. Watson; Samuel L. Marion; Photini Faith Rice; David L. Bentley; David Besselsen; Urs Utzinger; Patricia B. Hoyer; Jennifer K. Barton
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Paper Abstract

Our goal is to use optical coherence tomography (OCT) and multiphoton microscopy (MPM) to detect early tumor development in a mouse model of ovarian neoplasia. We hope to use information regarding early tumor development to create a diagnostic test for high-risk patients. In this study we collect in vivo images using OCT, second harmonic generation and two-photon excited fluorescence from non-vinylcyclohexene diepoxide (VCD)-dosed and VCD-dosed mice. VCD causes follicular apoptosis (simulating menopause) and leads to tumor development. Using OCT and MPM we visualized the ovarian microstructure and were able to see differences between non-VCD-dosed and VCD-dosed animals. This leads us to believe that OCT and MPM may be useful for detecting changes due to early tumor development.

Paper Details

Date Published: 19 March 2013
PDF: 9 pages
Proc. SPIE 8577, Optical Biopsy XI, 85770P (19 March 2013); doi: 10.1117/12.1000273
Show Author Affiliations
Jennifer M. Watson, The Univ. of Arizona (United States)
Samuel L. Marion, The Univ. of Arizona (United States)
Photini Faith Rice, The Univ. of Arizona (United States)
David L. Bentley, The Univ. of Arizona (United States)
David Besselsen, The Univ. of Arizona (United States)
Urs Utzinger, The Univ. of Arizona (United States)
Patricia B. Hoyer, The Univ. of Arizona (United States)
Jennifer K. Barton, The Univ. of Arizona (United States)


Published in SPIE Proceedings Vol. 8577:
Optical Biopsy XI
Robert R. Alfano; Stavros G. Demos, Editor(s)

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