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Proceedings Paper

Multimodal imaging of ischemic wounds
Author(s): Shiwu Zhang; Surya Gnyawali; Jiwei Huang; Peng Liu; Gayle Gordillo; Chandan K. Sen; Ronald Xu
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Paper Abstract

The wound healing process involves the reparative phases of inflammation, proliferation, and remodeling. Interrupting any of these phases may result in chronically unhealed wounds, amputation, or even patient death. Quantitative assessment of wound tissue ischemia, perfusion, and inflammation provides critical information for appropriate detection, staging, and treatment of chronic wounds. However, no method is available for noninvasive, simultaneous, and quantitative imaging of these tissue parameters. We integrated hyperspectral, laser speckle, and thermographic imaging modalities into a single setup for multimodal assessment of tissue oxygenation, perfusion, and inflammation characteristics. Advanced algorithms were developed for accurate reconstruction of wound oxygenation and appropriate co-registration between different imaging modalities. The multimodal wound imaging system was validated by an ongoing clinical trials approved by OSU IRB. In the clinical trial, a wound of 3mm in diameter was introduced on a healthy subject’s lower extremity and the healing process was serially monitored by the multimodal imaging setup. Our experiments demonstrated the clinical usability of multimodal wound imaging.

Paper Details

Date Published: 11 December 2012
PDF: 8 pages
Proc. SPIE 8553, Optics in Health Care and Biomedical Optics V, 85531G (11 December 2012); doi: 10.1117/12.1000018
Show Author Affiliations
Shiwu Zhang, Univ. of Science and Technology of China (China)
The Ohio State University (United States)
Surya Gnyawali, The Ohio State Univ. (United States)
Jiwei Huang, The Ohio State Univ. (United States)
Peng Liu, Univ. of Science and Technology of China (China)
Gayle Gordillo, The Ohio State Univ. (United States)
Chandan K. Sen, The Ohio State Univ. (United States)
Ronald Xu, Univ. of Science and Technology of China (China)
The Ohio State Univ. (United States)


Published in SPIE Proceedings Vol. 8553:
Optics in Health Care and Biomedical Optics V
Qingming Luo; Ying Gu; Xingde D. Li, Editor(s)

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