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Proceedings Paper

Tracing and quantification of pharmaceuticals using MR imaging and spectroscopy at clinical MRI system
Author(s): Eun-Kee Jeong; Xin Liu; Xianfeng Shi; Y. Bruce Yu; Zeng-Rong Lu
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Paper Abstract

Magnetic resonance imaging (MRI) and spectroscopy (MRS) is very powerful modality for imaging and localized investigation of biological tissue. Medical MRI measures nuclear magnetization of the water protons, which consists of 70 % of our body. MRI provides superior contrast among different soft tissues to all other existing medical imaging modalities, including ultrasound, X-ray CT, PET, and SPECT. In principle, MRI/S may be an ideal non-invasive tool for drug delivery research. However, because of its low sensitivity, a large dose is required for tracing pharmaceuticals. Therefore, its use for imaging of pharmaceuticals is very limited mostly to molecules that contain a paramagnetic metal ion, such as gadolinium (Gd3+) and manganese (Mn2+). The paramagnetic metal ion provides a large fluctuating magnetic field at the proton in the water molecule via a coordinate site. The measurement of local drug concentration is the first step for further quantification. Local concentration of the paramagnetic-ion based MRI contrast agent can be indirectly measured via the change in the water signal intensity. 19F MRI/S of fluorinated complex may be an option for drug delivery and tracing agent, because the fluorinated molecule may be directly detected due to its large magnetic moment (94 % of proton) and 100 % abundance.

Paper Details

Date Published: 24 October 2012
PDF: 9 pages
Proc. SPIE 8548, Nanosystems in Engineering and Medicine, 854845 (24 October 2012); doi: 10.1117/12.1000015
Show Author Affiliations
Eun-Kee Jeong, Utah Ctr. for Advanced Imaging Research (United States)
The Univ. of Utah (United States)
Xin Liu, Univ. of California, San Francisco (United States)
Xianfeng Shi, The Univ. of Utah (United States)
Y. Bruce Yu, Univ. of Maryland, Baltimore (United States)
Zeng-Rong Lu, Case Western Reserve Univ. (United States)


Published in SPIE Proceedings Vol. 8548:
Nanosystems in Engineering and Medicine
Sang H. Choi; Jin-Ho Choy; Uhn Lee; Vijay K. Varadan, Editor(s)

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