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Optical Engineering

Nuclear Medicine Imaging with Pressurized Multiwire Proportional Chambers
Author(s): Leon Kaufman; L. Blumin; R. Cavalieri; V. Perez-Mendez; Gerald Stoker
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Paper Abstract

The pressurized xenon-filled multi-wire proportional chamber (MWPC) is an imaging detector with high intrinsic spatial resolution and good uniformity of response. We describe the design and operation of a 20 x 20 cm2 MWPC with a mass of 0.14 g/cm2 of xenon, maintained at 60 psi absolute. Electromagnetic delay-lines are used to obtain position information. Imaging studies have been performed using a Nuclear Chicago low-energy high-resolution collimator. The intrinsic resolution of the system was determined for 60 keV and 140 keV photons using bar phantoms, and was found to be 1 mm and 2 mm respectively. The Modulation Transfer Function for 140 keV is down to 70 percent response at 1.4 cycles per cm. Stopping-power is about 65 percent for 1-125 and 10 percent for Tc-99m. The distribution of thyroid hormones in the rat was clearly demonstrated. Picker thyroid phantoms filled with 1-125 and TC-99m were imaged with good detail. Preliminary 1-125 thyroid studies in humans have shown a promising potential. Other studies in rats have included liver/spleen imaging with Tc-99m-sulfur colloid and skeletal imaging with Tc-99m-polyphosphate. The excellent spatial resolution of the detector, together with the addition of higher efficiency collimators and operation at higher pressures realize a system with characteristics that are adequate for clinical use. These components are now being incorporated in a 30 x 30 cm2 MWPC.

Paper Details

Date Published: 1 April 1974
PDF: 4 pages
Opt. Eng. 13(2) 132126 doi: 10.1117/12.7971684
Published in: Optical Engineering Volume 13, Issue 2
Show Author Affiliations
Leon Kaufman, University of California (United States)
L. Blumin, Veterans Administration Hospital (United States)
R. Cavalieri, Veterans Administration Hospital (United States)
V. Perez-Mendez, University of California (United States)
Gerald Stoker, Lawrence Berkeley Laboratory (United States)

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